Molecular docking analysis of AGTR1 antagonists

Cardiovascular diseases (CVDs) are the leading cause of death and morbidity globally. The renin-angiotensin system is an important regulatory for maintaining cardiovascular renal function. Therefore, angiotensin-converting enzyme inhibitors angiotensin receptor blockers have emerged as first-line treatments conditions such hypertension heart failure. Currently available synthetic medications used to treat various CVDs been linked with adverse effects. this study focuses on targeting type-1 II (AGTR1) by natural compounds. ZINC database compounds standard AGTR1 screened against active site. results showed that five compounds, namely ZINC85625504, ZINC62001623, ZINC70666587, ZINC06624086, ZINC95486187, had similar binding energies established inhibitors. These were found interact crucial residues, indicating their potential Moreover, hit demonstrated favorable drug-like characteristics warrant further investigation use in managing CVD.